John Neville ... Sherlock Holmes
Donald Houston ... Dr. John Watson
John Fraser ... Lord Carfax, Richard Osborne
Anthony Quayle ... Dr. Murray
Barbara Windsor ... Annie Chapman
Adrienne Corri ... Angela
Frank Finlay ... Insp. Lestrade
Judi Dench ... Sally
Charles Regnier ... Joseph Beck (as Charles Regnier)
Cecil Parker ... Prime Minister
Georgia Brown ... Singer
Barry Jones ... Duke of Shires
Robert Morley ... Mycroft Holmes
Dudley Foster ... Home Secretary
Peter Carsten ... Max Steiner